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      Coordinating assembly of a bacterial macromolecular machine

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      Nature reviews. Microbiology

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          Abstract

          The assembly of large and complex organelles, such as the bacterial flagellum, poses the formidable problem of coupling temporal gene expression to specific stages of the organelle-assembly process. The discovery that levels of the bacterial flagellar regulatory protein FlgM are controlled by its secretion from the cell in response to the completion of an intermediate flagellar structure (the hook–basal body) was only the first of several discoveries of unique mechanisms that coordinate flagellar gene expression with assembly. In this Review, we discuss this mechanism, together with others that also coordinate gene regulation and flagellar assembly in Gram-negative bacteria.

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          Author and article information

          Journal
          101190261
          31733
          Nat Rev Microbiol
          Nat. Rev. Microbiol.
          Nature reviews. Microbiology
          1740-1526
          1740-1534
          9 May 2018
          June 2008
          22 May 2018
          : 6
          : 6
          : 455-465
          Affiliations
          Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, Utah 84112, USA
          Author notes
          Correspondence to K.T.H. kelly.hughes@ 123456utah.edu
          Article
          PMC5963726 PMC5963726 5963726 nihpa964761
          10.1038/nrmicro1887
          5963726
          18483484
          ea6580dc-a503-4161-8ad4-cb5963b77f68
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