Spatial-temporal epidemiology of human Salmonella Enteritidis infections with major phage types (PTs 1, 4, 5b, 8, 13, and 13a) in Ontario, Canada, 2008–2009

Abstract

Background

In Ontario and Canada, the incidence of human Salmonella enterica serotype Enteritidis ( S. Enteritidis) infections have increased steadily during the last decade. Our study evaluated the spatial and temporal epidemiology of the major phage types ( PTs) of S. Enteritidis infections to aid public health practitioners design effective prevention and control programs.

Methods

Data on S. Enteritidis infections between January 1, 2008 and December 31, 2009 were obtained from Ontario’s disease surveillance system. Salmonella Enteritidis infections with major phage types were classified by their annual health region-level incidence rates ( IRs), monthly IRs, clinical symptoms, and exposure settings. A scan statistic was employed to detect retrospective phage type-specific spatial, temporal, and space-time clusters of S. Enteritidis infections. Space-time cluster cases’ exposure settings were evaluated to identify common exposures.

Results

1,336 cases were available for analysis. The six most frequently reported S. Enteritidis PTs were 8 ( n = 398), 13a ( n = 218), 13 ( n = 198), 1 ( n = 132), 5b ( n = 83), and 4 ( n = 76). Reported rates of S. Enteritidis infections with major phage types varied by health region and month. International travel and unknown exposure settings were the most frequently reported settings for PT 5b, 4, and 1 cases, whereas unknown exposure setting, private home, food premise, and international travel were the most frequently reported settings for PT 8, 13, and 13a cases.

Diarrhea, abdominal pain, and fever were the most commonly reported clinical symptoms. A number of phage type-specific spatial, temporal, and space-time clusters were identified. Space-time clusters of PTs 1, 4, and 5b occurred mainly during the winter and spring months in the North West, North East, Eastern, Central East, and Central West regions. Space-time clusters of PTs 13 and 13a occurred at different times of the year in the Toronto region. Space-time clusters of PT 8 occurred at different times of the year in the North West and South West regions.

Conclusions

Phage type-specific differences in exposure settings, and spatial-temporal clustering of S. Enteritidis infections were demonstrated that might guide public health surveillance of disease outbreaks. Our study methodology could be applied to other foodborne disease surveillance data to detect retrospective high disease rate clusters, which could aid public health authorities in developing effective prevention and control programs.

Electronic supplementary material

The online version of this article (doi:10.1186/s12889-015-2592-6) contains supplementary material, which is available to authorized users.