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      Augmenting effect of opioid peptides on murine macrophage activation

      , , ,

      Journal of Neuroimmunology

      Elsevier BV

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          Abstract

          We investigated the effect of several opioid peptides on the activation of murine peritoneal exudate macrophages (M phi) in vitro. M phi were treated with interferon (IFN) as a priming agent and bacterial lipopolysaccharide (LPS) as a triggering agent in the presence or absence of opioid peptides. M phi activation was assessed by their tumoricidal activity. When treatment with IFN and LPS resulted in a high level activation of M phi, dynorphin-A exerted no further enhancing effect. When treatment induced only weak activation, however, dynorphin-A augmented the M phi activation. Leucine-enkephalin, methionine-enkephalin, and also beta-endorphin had augmenting effects. An opioid receptor antagonist, naloxone, reduced the effect of dynorphin-A and beta-endorphin. When M phi were treated sequentially with IFN and LPS, beta-endorphin operated in combination with LPS only. Moreover, beta-endorphin was effective for already activated M phi. These results indicate that opioid peptides act on M phi via classical opioid receptors, and that responsiveness to opioid peptides is induced in the triggering stage of M phi activation.

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          Author and article information

          Journal
          Journal of Neuroimmunology
          Journal of Neuroimmunology
          Elsevier BV
          01655728
          February 1994
          February 1994
          : 50
          : 1
          : 71-76
          Article
          10.1016/0165-5728(94)90216-X
          7905488
          © 1994

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