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      Evidence that Glyburide-Induced Diuresis is not Mediated by Inhibition of ADH

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      Hormone Research in Paediatrics

      S. Karger AG

      Glyburide, ADH, Diuresis, Diabetes insipidus

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          The sulfonylurea, chlorpropamide, has a well defined antidiuretic effect mediated both through increased ADH release and potentiation of ADH action on the kidney. In contrast, the sulfonylureas tolazamide, acetohexamide and glyburide have diuretic actions. The diuretic actions of glyburide is not mediated through inhibition of ADH release or interference with the renal action of ADH. Therefore glyburide, and presumably the other diuretic sulfonylureas, apparently have diuretic actions by means of a direct renal effect, perhaps by altering renal hemo-dynamics or by acting on the renal tubule.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          21 November 2008
          : 5
          : 6
          : 359-366
          Endocrinology Section, VA Hospital, and Departments of Medicine and Pharmacology, State University of New York, Upstate Medical Center, Syracuse, N.Y.
          178651 Horm Res 1974;5:359–366
          © 1974 S. Karger AG, Basel

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          Pages: 8


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