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      Evidence that Glyburide-Induced Diuresis is not Mediated by Inhibition of ADH

      , ,

      Hormone Research in Paediatrics

      S. Karger AG

      Glyburide, ADH, Diuresis, Diabetes insipidus

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          Abstract

          The sulfonylurea, chlorpropamide, has a well defined antidiuretic effect mediated both through increased ADH release and potentiation of ADH action on the kidney. In contrast, the sulfonylureas tolazamide, acetohexamide and glyburide have diuretic actions. The diuretic actions of glyburide is not mediated through inhibition of ADH release or interference with the renal action of ADH. Therefore glyburide, and presumably the other diuretic sulfonylureas, apparently have diuretic actions by means of a direct renal effect, perhaps by altering renal hemo-dynamics or by acting on the renal tubule.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1974
          1974
          21 November 2008
          : 5
          : 6
          : 359-366
          Affiliations
          Endocrinology Section, VA Hospital, and Departments of Medicine and Pharmacology, State University of New York, Upstate Medical Center, Syracuse, N.Y.
          Article
          178651 Horm Res 1974;5:359–366
          10.1159/000178651
          4214743
          © 1974 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
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