Blog
About

371
views
0
recommends
+1 Recommend
0 collections
    51
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Molecular portraits of human breast tumours.

      Nature

      Breast Neoplasms, Tumor Cells, Cultured, Phenotype, Oligonucleotide Array Sequence Analysis, Humans, Genes, erbB-2, Gene Expression Profiling, Gene Expression, Female, DNA, Neoplasm, genetics

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Human breast tumours are diverse in their natural history and in their responsiveness to treatments. Variation in transcriptional programs accounts for much of the biological diversity of human cells and tumours. In each cell, signal transduction and regulatory systems transduce information from the cell's identity to its environmental status, thereby controlling the level of expression of every gene in the genome. Here we have characterized variation in gene expression patterns in a set of 65 surgical specimens of human breast tumours from 42 different individuals, using complementary DNA microarrays representing 8,102 human genes. These patterns provided a distinctive molecular portrait of each tumour. Twenty of the tumours were sampled twice, before and after a 16-week course of doxorubicin chemotherapy, and two tumours were paired with a lymph node metastasis from the same patient. Gene expression patterns in two tumour samples from the same individual were almost always more similar to each other than either was to any other sample. Sets of co-expressed genes were identified for which variation in messenger RNA levels could be related to specific features of physiological variation. The tumours could be classified into subtypes distinguished by pervasive differences in their gene expression patterns.

          Related collections

          Author and article information

          Journal
          10.1038/35021093
          10963602

          Comments

          Comment on this article