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      Association of Copeptin, a Surrogate Marker of Arginine Vasopressin, with Decreased Kidney Function in Sugarcane Workers in Guatemala


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          Background: Vasopressin is elevated in response to heat and dehydration and has been postulated to have a role in the chronic kidney disease of unknown origin being observed in Central America. The aims of this study were to examine whether the vasopressin pathway, as measured by copeptin, is associated with the presence of kidney dysfunction, and to examine whether higher fluid intake is associated with lower circulating copeptin and thereby preserves kidney health among sugarcane workers exposed to hot conditions. Methods: Utilizing a longitudinal study of 105 workers in Guatemala, we examined relationships between hydration indices, plasma copeptin concentrations, and kidney function markers at 3 times during the 6-month harvest. We also examined whether baseline copeptin concentrations increased the odds of developing an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m<sup>2</sup>. Results: Copeptin concentrations were positively associated with serum creatinine (β 1.41, 95% CI 0.88–2.03) and negatively associated with eGFR (β –1.07, 95% CI –1.43 to –0.70). In addition, as workers improved their hydration (measured by increases in fluid balance), copeptin concentrations were reduced, and this reduction was associated with an improvement in kidney function. Conclusions: Results suggest that copeptin should be studied as a potential prognostic biomarker.

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          Author and article information

          Ann Nutr Metab
          Annals of Nutrition and Metabolism
          S. Karger AG
          April 2020
          13 March 2020
          : 76
          : 1
          : 30-36
          [_a] aCenter for Health, Work, and Environment, Colorado School of Public Health, University of Colorado, Aurora, Colorado, USA
          [_b] bDepartment of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado, Aurora, Colorado, USA
          [_c] cColorado Consortium on Climate Change and Human Health, University of Colorado, Aurora, Colorado, USA
          [_d] dDivision of Renal Diseases and Hypertension, Department of Medicine, School of Medicine, University of Colorado, Aurora, Colorado, USA
          [_e] eDivision of Kinesiology and Health, University of Wyoming, Laramie, Wyoming, USA
          [_f] fDepartment of Cardio-Renal Physiopathology, Instituto Nacional de Cardiología-Ignacio Chávez, Mexico City, Mexico
          [_g] gDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, School of Medicine, Aurora, Colorado, USA
          [_h] hDepartment of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, Colorado, USA
          Author notes
          *Jaime Butler-Dawson, Center for Health, Work, and Environment, Colorado School of Public Health, 13001 E. 17th Pl., Ste. W3111, Aurora, CO 80045 (USA), E-Mail Jaime.butler-dawson@cuanschutz.edu
          506619 Ann Nutr Metab 2020;76:30–36
          © 2020 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          : 05 December 2019
          : 16 February 2020
          Page count
          Tables: 3, Pages: 7
          Basic/Transitional Science: Research Article

          Nutrition & Dietetics,Health & Social care,Public health
          Kidney,Hydration,Agricultural workers,Vasopressin


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