Journal ID (nlm-journal-id): 0410462
Journal ID (pubmed-jr-id): 6011
Journal ID (nlm-ta): Nature
Title:
Nature
ISSN
(Print):
0028-0836
ISSN
(Electronic):
1476-4687
Publication date Nihms-submitted: 5
September
2008
Publication date
(Print):
23
October
2008
Publication date PMC-release: 23
April
2009
Volume: 455
Issue: 7216
Pages: 1076-1081
Affiliations
[1
]
Departments of Pediatric Oncology and the Program in Cancer Chemical Biology, Dana-Farber
Cancer Institute, the Division of Hematology/Oncology, Children’s Hospital Boston,
and the Department of Pediatrics, Harvard Medical School, Boston, MA, 02115, USA
[2
]
Laboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, National
Institutes of Health, Bethesda, MD 20892 USA
[3
]
Departments of Medicine and Pathology and Immunology, Washington University School
of Medicine, St. Louis, MO 63110 USA
Author notes
Author Information Structural coordinates have been submitted to the PDB database under accession code
2K7W. Reprints and permission information is available at www.nature.com/reprints.
The authors declare competing financial interests: L.D.W. is a scientific advisory
board member and consultant for Aileron Therapeutics, Inc. Correspondence and requests
for materials should be addressed to N.T. (
tjandran@
123456nhlbi.nih.gov
) or L.D.W. (
loren_walensky@
123456dfci.harvard.edu
).
[*]
These authors contributed equally to this work
Author Contributions G.H.B. and L.D.W. designed, synthesized, and characterized the SAHBs for structural
and biological studies. M.S. and N.T. performed the NMR analysis of BAX and BIM SAHB,
and E.G. and L.D.W. conducted the PRE-NMR analysis of BAX using MTSL-derivatized SAHBs
and performed the structure calculations. E.G., M.L.D., and K.P. executed the
in vitro BAX activation studies. H.-C.T., H.K., and E.H.-Y.C. generated the BAX-reconstituted
DKO MEFs and analyzed their response to staurosporine, whereas S.G.K. examined the
cellular response to BIM SAHB treatment.
Article
Manuscript ID: NIHMS68617
DOI: 10.1038/nature07396
PMC ID: 2597110
PubMed ID: 18948948
SO-VID: ea9cbecc-8b05-4782-baed-ec0a79076ed1
Funded by: National Cancer Institute : NCI
Funded by: National Heart, Lung, and Blood Institute : NHLBI
Award ID: R01 CA125562-02
||CA
Funded by: National Cancer Institute : NCI
Funded by: National Heart, Lung, and Blood Institute : NHLBI
Award ID: K99 HL095929-02
||HL
Funded by: National Cancer Institute : NCI
Funded by: National Heart, Lung, and Blood Institute : NHLBI
Award ID: K99 HL095929-01A1
||HL