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      Thalamocortical changes in major depression probed by deconvolution and physiology-based modeling.

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      NeuroImage

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          Abstract

          Auditory event-related potentials (ERPs) have been extensively studied in patients with depression, but most studies have focused on purely phenomenological analysis methods, such as component scoring. In contrast, this study applies two recently developed physiology-based methods-fitting using a thalamocortical model of neuronal activity and waveform deconvolution - to data from a selective-attention task in four subject groups (49 patients with melancholic depression, 34 patients with non-melancholic depression, 111 participants with subclinical depressed mood, and 98 healthy controls), to yield insight into physiological differences in attentional processing between participants with major depression and controls. This approach found evidence that: participants with depressed mood, regardless of clinical status, shift from excitation in the thalamocortical system towards inhibition; that clinically depressed participants have decreased relative response amplitude between target and standard waveforms; and that patients with melancholic depression also have increased thalamocortical delays. These findings suggest possible physiological mechanisms underlying different depression subtypes, and may eventually prove useful in motivating new physiology-based diagnostic methods.

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          Author and article information

          Journal
          Neuroimage
          NeuroImage
          1095-9572
          1053-8119
          Feb 14 2011
          : 54
          : 4
          Affiliations
          [1 ] School of Physics, University of Sydney, New South Wales, Australia. ckerr@physics.usyd.edu.au
          Article
          S1053-8119(10)01438-2
          10.1016/j.neuroimage.2010.11.008
          21073966
          ea9ec64c-a9d9-4aa5-b522-d1c43aaf0897
          Copyright © 2010 Elsevier Inc. All rights reserved.
          History

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