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      Recombinant human soluble thrombomodulin treatment for acute exacerbation of idiopathic pulmonary fibrosis: a retrospective study.

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          Abstract

          Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) can be fatal, and abnormalities in the coagulation system of patients with AE-IPF have been reported. Recombinant human soluble thrombomodulin (rhTM) forms a complex with thrombin to inactivate coagulation. It also inhibits high-mobility group box protein 1 (HMGB-1), which results in the suppression of inflammation.

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          Author and article information

          Journal
          Respiration
          Respiration; international review of thoracic diseases
          1423-0356
          0025-7931
          2015
          : 89
          : 3
          Affiliations
          [1 ] Division of Respiratory Medicine, Toho University Omori Medical Center, Tokyo, Japan.
          Article
          000369828
          10.1159/000369828
          25659984
          eaa44e11-ef0b-4672-8192-2b02475c82a2
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