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Blocking LDHA glycolytic pathway sensitizes glioblastoma cells to radiation and temozolomide
Michael Koukourakis ,
Avgi Tsolou ,
Stamatia Pouliliou ,
Ioannis Lamprou ,
Maria Papadopoulou ,
Maria Ilemosoglou ,
Georgia Kostoglou ,
Dimitra Ananiadou ,
Efthimios Sivridis ,
Alexandra Giatromanolaki
September 2017
September 2017
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Abstract
Up-regulation of lactate dehydrogenase LDHA, is a frequent event in human malignancies
and relate to poor postoperative outcome. In the current study we examined the hypothesis
that LDHA and anaerobic glycolysis, may contribute to the resistance of glioblastoma
to radiotherapy and to temozolomide.