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      Increased arterial oxygen content by artificial haemoglobin induces a decrease in regional cerebral blood flow and decreased regional cerebral oxygen delivery.

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          Abstract

          Under physiological conditions, cerebral oxygen delivery is kept constant by adaptation of the regional cerebral blood flow (CBF) in relation to the oxygen content. So far, decreases of the regional CBF induced by a higher arterial oxygen content have been produced under hyperbaric or hyperviscous conditions. We tested whether local CBF is also reduced by a high haemoglobin (Hb) concentration at a normal haematocrit (Hct).

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          Author and article information

          Journal
          Eur J Anaesthesiol
          European journal of anaesthesiology
          1365-2346
          0265-0215
          Mar 2009
          : 26
          : 3
          Affiliations
          [1 ] Clinic for Anesthesiology and Critical Care Medicine, Medical Faculty Mannheim, Germany.
          Article
          19244699
          eab9cb6e-d3b9-446a-8de3-d5faa7f3a21d
          History

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