Proteinase-activated receptor 1 contributed to up-regulation of enkephalin in keratinocytes of patients with obstructive jaundice.

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Abstract

Skin synthesis of endogenous opioids such as enkephalin is considered to be increased in cholestatic rodents, which may induce antinociception in cholestatic liver disease. No studies have reported yet the expression of skin enkephalin in patients with cholestasis.

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Journal

Journal ID (iso-abbrev): Anesthesiology

Title: Anesthesiology

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1528-1175

ISSN (Print): 0003-3022

Publication date (Electronic): Jul 2014

Volume: 121

Issue: 1

Affiliations

[1 ] From the Department of Anesthesiology and Intensive Care Unit, Eastern Hepatobiliary Surgery Hospital, the Second Military Medical University, Shanghai, China (K.-M.T., Y.T., C.-Y.C., L.-Q.Y., Z.-J.L., Y.-M.S., W.-F.Y.); and Department of Cardiothoracic Surgery, Institute of Cardiothoracic Surgery, Changhai Hospital, the Second Military Medical University, Shanghai, China (S.-D.H.).

Article

DOI: 10.1097/ALN.0000000000000210

PubMed ID: 24614324

SO-VID: ead060a5-e2e3-4539-864d-d7e867773b57

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