0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Experience with Insulin-Induced Hypoglycemia as a Provocative Test for Growth Hormone and Cortisol Secretion in Children

      Read this article at

      ScienceOpenPublisher
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Insulin-induced hypoglycemia has been used in 109 children with a variety of disorders to assess the hypothalamo-pituitary adrenal axis.The patients were divided into 3 groups: (1) patients with growth retardation and with various disorders where an involvement of the hypothalamo-pituitary region was suspected; (2) obese patients; (3) specific syndromes: spontaneous hypoglycemia, anorexia nervosa, Turner’s syndrome, craniopharyngioma. Glucose, free fatty acids, cortisol and growth hormone were measured before injection of insulin, and at 20-min-intervals thereafter for a period of 2–4 h. The findings, particularly in obesity and in syndromes other than growth disorders have shown, that a series of factors have to be considered for a correct interpretation of the hormonal response to hypoglycemia. The limits for normal, reduced or absent response are given and as a simple screening for growth hormonee deficiency, a growth hormone estimation without stimulation can be used. The test has been found safe under clinical conditions and to provide reliable information about growth hormone and ACTH, respectively cortisol reaction.

          Related collections

          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1971
          1971
          21 November 2008
          : 2
          : 6
          : 338-365
          Affiliations
          University Children’s Hospital, Basle
          Article
          178247 Hormones 1971;2:338–365
          10.1159/000178247
          © 1971 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 28
          Categories
          Paper

          Comments

          Comment on this article