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      Acute Renal Failure in a Renal Transplant Donor due to Primary Antiphospholipid Syndrome

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          Primary antiphospholipid antibody (APA) syndrome, a common prothrombotic disorder, has been known in dialysis patients and renal transplant recipients. We report a case of primary APA syndrome presenting as a posttransplant complication in a renal transplant donor. A renal donor presented with acute, painless anuria due to renal artery thrombosis 6 years following renal transplant surgery, subsequent thrombosis of jugular catheter and arteriovenous fistula occurred, despite anticoagulation treatment, due to primary APA syndrome. This incident represents the most catastrophic complication reported in a renal donor due to primary APA syndrome. The validity of a prothrombotic assay in an organ donor workup to detect predilection to hypercoagulable disorders and to prevent such complications is open to question. The actual significance of APA in the blood is unclear; hence, the presence of APA in a potential renal donor would pose an ethical and practical dilemma.

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          Author and article information

          Am J Nephrol
          American Journal of Nephrology
          S. Karger AG
          February 2001
          12 March 2001
          : 21
          : 1
          : 55-57
          Division of Nephrology, Department of Medicine, Seth G.S. Medical College and K.E.M. Hospital, University of Bombay, India
          46220 Am J Nephrol 2001;21:55–57
          © 2001 S. Karger AG, Basel

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