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      A Factor in Lymph Node and Spleen Induced by Restraint Stress in Mice and Rats Suppresses Lymphocyte Proliferation

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          Abstract

          Extracts from lymph node and spleen in mice and rats subjected to restraint stress significantly suppressed lymphocyte proliferation, but extracts from brain, skeletal muscle, and thymus gland had no effect on lymphocyte proliferation, suggesting that a suppressive factor for lymphocyte proliferation might selectively be induced in lymph node and spleen. Further experiments showed that biochemical properties, molecular weight, correlation between suppressive factors in serum and in extract of the lymph tissue from stressed animals, and control of the generation, all indicated that under the conditions of restraint stress and under the control of central nervous system a suppressive factor was generated in peripheral lymph tissue and then released into the blood-stream, which acted as a strong suppressor of lymphocyte proliferation.

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          Author and article information

          Journal
          NIM
          Neuroimmunomodulation
          10.1159/issn.1021-7401
          Neuroimmunomodulation
          S. Karger AG
          1021-7401
          1423-0216
          1995
          1995
          02 May 1996
          : 2
          : 5
          : 274-281
          Affiliations
          Departments of a Physiology and b Immunology, Beijing Medical University. Beijing, People's Republic of China
          Article
          97206 Neuroimmunomodulation 1995;2:274–281
          10.1159/000097206
          8739200
          © 1995 S. Karger AG, Basel

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          Page count
          Pages: 8
          Categories
          Original Paper

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