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      Influence of Middle-Sized Molecule Aggregates from Dialysate of Uremic Patients on Lymphocyte Transformation in vitro

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          Abstract

          It was found that middle-sized molecules obtained from dialysate of uremic patients caused suppression of PHA-induced lymphocyte transformation. This was expressed by the lowering of labeled leucine incorporation and by the suppression of lymphocyte transformation as morphologically assessed. In view of the presented data middle-sized molecules seem to be biologically active substances.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1976
          1976
          28 November 2008
          : 17
          : 1
          : 73-80
          Affiliations
          Renal Clinic and Department of Histology, Medical Academy and Institute of Molecular Biochemistry, Jagiellonian University, Cracow
          Article
          180713 Nephron 1976;17:73–80
          10.1159/000180713
          934415
          eb0e3180-b07b-4613-97c6-1dd31b3fbaaa
          © 1976 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 06 February 1975
          : 25 August 1975
          Page count
          Pages: 8
          Categories
          Original Paper

          Cardiovascular Medicine,Nephrology
          Dialysate,Radioactive leucine incorporation,Lymphocyte transformation,Uremia,Middle-sized molecules

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