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      Plaque Removal and Thrombus Dissolution with the Photoacoustic Energy of Pulsed-Wave Lasers – Biotissue Interactions and Their Clinical Manifestations

      Cardiology

      S. Karger AG

      Laser, Thrombolysis, Coronary, Thrombus, Atherosclerosis, Plaque

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          Abstract

          Pulsed-wave lasers ablate atherosclerotic plaque and dissolve coronary thrombus by emission of photoacoustic energy initiating photomechanical, photochemical and photothermal transformation. The newly discovered process of ‘inertially confined ablation’ ascribes to pressure generation and plaque vaporization during lasing. Tremendous pressure within the lased plaque and gas bubble formation account for adverse clinical manifestations such as perforations, acute vessel closure and dissections. Pulsed-wave lasers can be applied for selected patients with lesions considered ‘nonideal’ for balloon angioplasty who present with acute ischemic syndromes. Due to strong optical absorption by thrombi in the ultraviolet (excimer), visible (dye), and mid-infrared (holmium) wavelengths, these lasers can also dissolve clots and therefore serve as an emerging option in patients with complicated acute myocardial infarction who fail to respond to thrombolytic drugs and exhibit thrombotic lesions deemed unsuitable for standard balloon angioplasty.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1996
          1996
          19 November 2008
          : 87
          : 5
          : 384-391
          Affiliations
          Interventional Cardiovascular Laboratories, Division of Cardiology, McGuire VA Medical Center, Medical College of Virginia, Richmond, Va., USA
          Article
          177125 Cardiology 1996;87:384–391
          10.1159/000177125
          8894258
          © 1996 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
          Categories
          General Cardiology, Review

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