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      Development of the retina and optic pathway.

      Vision Research
      Animals, Cell Differentiation, physiology, Humans, Mice, Rats, Retina, cytology, Retinal Neurons, Visual Pathways

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          Abstract

          Our understanding of the development of the retina and visual pathways has seen enormous advances during the past 25years. New imaging technologies, coupled with advances in molecular biology, have permitted a fuller appreciation of the histotypical events associated with proliferation, fate determination, migration, differentiation, pathway navigation, target innervation, synaptogenesis and cell death, and in many instances, in understanding the genetic, molecular, cellular and activity-dependent mechanisms underlying those developmental changes. The present review considers those advances associated with the lineal relationships between retinal nerve cells, the production of retinal nerve cell diversity, the migration, patterning and differentiation of different types of retinal nerve cells, the determinants of the decussation pattern at the optic chiasm, the formation of the retinotopic map, and the establishment of ocular domains within the thalamus. Copyright © 2010 Elsevier Ltd. All rights reserved.

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          Author and article information

          Journal
          20647017
          2974959
          10.1016/j.visres.2010.07.010

          Chemistry
          Animals,Cell Differentiation,physiology,Humans,Mice,Rats,Retina,cytology,Retinal Neurons,Visual Pathways
          Chemistry
          Animals, Cell Differentiation, physiology, Humans, Mice, Rats, Retina, cytology, Retinal Neurons, Visual Pathways

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