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      MicroRNA-210 regulates cancer cell proliferation through targeting fibroblast growth factor receptor-like 1 (FGFRL1).

      The Journal of Biological Chemistry

      3' Untranslated Regions, genetics, Base Sequence, Carcinoma, Squamous Cell, pathology, Cell Cycle, Cell Death, Cell Differentiation, Cell Line, Tumor, Cell Proliferation, Down-Regulation, Esophageal Neoplasms, Gene Expression Regulation, Neoplastic, Genes, Neoplasm, Humans, MicroRNAs, metabolism, Receptor, Fibroblast Growth Factor, Type 5

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          Abstract

          The importance of microRNAs (miRNAs) in human malignancies has been well recognized. Here, we report that the expression of microRNA-210 (miR-210) is down-regulated in human esophageal squamous cell carcinoma and derived cell lines. Marked decreases in the level of miR-210 were observed especially in poorly differentiated carcinomas. We found that miR-210 inhibits cancer cell survival and proliferation by inducing cell death and cell cycle arrest in G(1)/G(0) and G(2)/M. Finally, we identified fibroblast growth factor receptor-like 1 (FGFRL1) as a target of miR-210 in esophageal squamous cell carcinoma and demonstrated that FGFRL1 accelerates cancer cell proliferation by preventing cell cycle arrest in G(1)/G(0). Taken together, our findings show an important role for miR-210 as a tumor-suppressive microRNA with effects on cancer cell proliferation.

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          Author and article information

          Journal
          21044961
          3013001
          10.1074/jbc.M110.170852

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