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      Celastrol inhibits hepatitis C virus replication by upregulating heme oxygenase-1 via the JNK MAPK/Nrf2 pathway in human hepatoma cells

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      Antiviral Research

      Elsevier BV

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          Abstract

          Celastrol, a quinone methide triterpene isolated from the root extracts of Tripterygium wilfordii, can greatly induce the gene expression activity of heme oxygenase-1 (HO-1) to achieve disease prevention and control. HO-1 induction was recently shown to result in anti-HCV activity by inducing type I interferon and inhibiting hepatitis C virus (HCV) NS3/4A protease activity. The aim of the present study is to evaluate the anti-HCV activity of celastrol and characterize its mechanism of inhibition.

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          Author and article information

          Journal
          Antiviral Research
          Antiviral Research
          Elsevier BV
          01663542
          October 2017
          October 2017
          : 146
          : 191-200
          10.1016/j.antiviral.2017.09.010
          28935193
          © 2017

          https://www.elsevier.com/tdm/userlicense/1.0/

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