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      Use of antipsychotic drugs in patients with Alzheimer's disease treated with rivastigmine versus donepezil: a retrospective, parallel-cohort, hypothesis-generating study.

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          Abstract

          Rivastigmine and donepezil are two cholinesterase inhibitors (ChEIs) indicated for the treatment of mild-to-moderate Alzheimer's disease. Dementia-related behavioural issues are typically managed by environmental modification and the use of psychotropics including antipsychotic medications. However, ChEIs have also been associated with reductions in behavioural symptoms in Alzheimer's disease patients. This retrospective, parallel-cohort, hypothesis-generating study investigated whether treatment with rivastigmine is associated with reduced prescription of antipsychotic medications compared with treatment with donepezil.

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          Author and article information

          Journal
          Drugs Aging
          Drugs & aging
          Springer Nature America, Inc
          1179-1969
          1170-229X
          Nov 01 2010
          : 27
          : 11
          Affiliations
          [1 ] Department of Neurology, Ohio State University, Columbus, Ohio 43210, USA.
          Article
          5
          10.2165/11584290-000000000-00000
          20964464

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