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      ¿Cómo interpreto un metaanálisis publicado en una revista científica? Translated title: How to understand a meta-analysis in a medical journal?

      research-article
      Angiología
      Arán Ediciones S.L.
      Metaanálisis, Revista científica, Interpretación, Meta-analysis, Medical journal, Interpretation

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          Abstract

          Resumen El objetivo del estudio es evaluar el resultado de las estatinas sobre diferentes aspectos de los AAA. Fijémonos que la frase anterior recoge la esencia ya comentada del metaanálisis: sintetizar con cocina estadística los resultados de diferentes diseños para sacar una única conclusión.

          Translated abstract

          Abstract The aim of the study is to assess the outcome of statins on different aspects of AAAs. Note that the above sentence captures the essence of meta-analysis: synthesising the results of different designs with statistical studies to draw a single conclusion.

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          Most cited references2

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          Statins Reduce Abdominal Aortic Aneurysm Growth, Rupture, and Perioperative Mortality: A Systematic Review and Meta‐Analysis

          Background There are no recognized pharmacological treatments for abdominal aortic aneurysms (AAA), although statins are suggested to be beneficial. We sought to summarize the literature regarding the effects of statins on human AAA growth, rupture, and 30‐day mortality. Methods and Results We conducted a systematic review and meta‐analysis of randomized and observational studies using the Cochrane CENTRAL database, MEDLINE, and EMBASE up to June 15, 2018. Review, abstraction, and quality assessment were conducted by 2 independent reviewers, and a third author resolved discrepancies. Pooled mean differences and odds ratios with 95% confidence intervals were calculated using random effects models. Heterogeneity was quantified using the I2 statistic, and publication bias was assessed using funnel plots. Our search yielded 911 articles. One case‐control and 21 cohort studies involving 80 428 patients were included. The risk of bias was low to moderate. Statin use was associated with a mean AAA growth rate reduction of 0.82 mm/y (95% confidence interval 0.33, 1.32, P=0.001, I2=86%). Statins were also associated with a lower rupture risk (odds ratio 0.63, 95% confidence interval 0.51, 0.78, P<0.0001, I2=27%), and preoperative statin use was associated with a lower 30‐day mortality following elective AAA repair (odds ratio 0.55, 95% confidence interval 0.36, 0.83, P=0.005, I2=57%). Conclusions Statin therapy may be associated with reduction in AAA progression, rupture, and lower rates of perioperative mortality following elective AAA repair. These data argue for widespread statin use in AAA patients. Clinical Trial Registration URL: http://www.crd.york.ac.uk. Unique identifier: CRD42017056480.
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            Metodología básica de la investigación

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              Author and article information

              Journal
              angiologia
              Angiología
              Angiología
              Arán Ediciones S.L. (Madrid, Madrid, Spain )
              0003-3170
              1695-2987
              February 2022
              : 74
              : 1
              : 22-26
              Affiliations
              [1] Madrid orgnameHospital Clínico San Carlos orgdiv1Cirugía Vascular y Endovascular orgdiv2Servicio de Angiología Spain
              Article
              S0003-31702022000100022 S0003-3170(22)07400100022
              10.20960/angiologia.00376
              eb55b5e5-f657-419f-8da8-74cdad57d240

              This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

              History
              : 02 December 2021
              : 03 December 2021
              Page count
              Figures: 0, Tables: 0, Equations: 0, References: 2, Pages: 5
              Product

              SciELO Spain

              Categories
              Artículo Especial

              Metaanálisis,Interpretation,Medical journal,Meta-analysis,Interpretación,Revista científica

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