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      Regional cerebral blood flow (rCBF) in schizophrenia during verbal memory activation: a 99mTc-HMPAO single photon emission tomography (SPET) study.

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          Abstract

          Regional cerebral blood flow (rCBF) was investigated in a group of medicated DSM-III-R schizophrenic patients and age, sex and handedness matched normal volunteers using a split-dose 99mTc-HMPAO Single Photon Emission Tomography (SPET) protocol. Measures were taken during the performance of a verbal memory task aimed at activating the left medial temporal lobe, a region repeatedly suggested to be structurally abnormal in schizophrenia. In normal subjects, the performance of the task was associated with significant rCBF increases in the left medial temporal, left inferior frontal and anterior cingulate cortices, and right cerebellum. Despite their significantly poorer performance on the memory task, the degree of medial temporal activation measured in the schizophrenic patients was not significantly different from that found in the control group. This finding suggests that memory deficits in schizophrenia do not necessarily imply failure to activate the left medial temporal lobe as assessed by 99mTc-HMPAO SPET.

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          Author and article information

          Journal
          Psychol Med
          Psychological medicine
          Cambridge University Press (CUP)
          0033-2917
          0033-2917
          May 1994
          : 24
          : 2
          Affiliations
          [1 ] Department of Neuroscience and Psychiatric Genetics, Institute of Psychiatry, London.
          Article
          10.1017/s0033291700027434
          8084941
          eb6986ce-cf24-43f6-8452-42b5af931558
          History

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