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      Setting Goals or Shifting Goalposts: Role of Frailty for Critical Care Decisions During COVID-19

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          Abstract

          Dear Editor, Frailty is characterized by a loss of physiological reserves leading to increased susceptibility to adverse outcomes with stressor events (1). With healthcare resources worldwide overstretched by the unprecedented COVID-19 pandemic, there is intense interest in reliable assessment tools to inform patient prioritization for scarce intensive care resource. Not surprisingly, frailty tools have been thrust into the spotlight as the panacea to age-based criteria for critical care triage decisions. However, detractors worry that rigid and indiscriminate application of frailty tools may ironically exacerbate the deprioritising of older adults and other vulnerable populations. Herein, we describe the 3F approach to guide thinking about the role of frailty in critical care decisions for older adults during the COVID-19 pandemic. Framing Setting goals of care versus shifting goalposts of care Frailty captures the health status of an older person and predicts adverse outcomes in the community and acute inpatient care settings. Over the years, geriatricians have promoted frailty as part of a patient-centred approach to assessment that is the cornerstone for rational context-appropriate goals of care (2). On this basis, there is keen interest in the development and broad uptake of convenient screening and assessment tools to assist in frailty identification amongst older people who access the healthcare system (1). Its utility in predicting adverse outcomes have also been examined in the intensive care unit (ICU) setting. Whilst the multidimensional measure of frailty such as Clinical Frailty Scale (CFS) and Frailty Index (FI) generally predict higher hospital mortality, longer length of stay, poor functional outcome and institutionalisation, these findings are not uniform across all studies (3). Notably, there are no outcome studies that examine the effectiveness of frailty for ICU triaging purposes. Using frailty for such a purpose would be akin to shifting goalposts of care with current knowledge. Framework Right instrument for the right purpose While frailty has value in allocation of scarce health resources, it also has limitations. Frailty does not invariably lead to adverse outcomes in older adults. In fact, a recent study demonstrated that the outcomes for frail patients more than 80 years of age can be good, with 91% surviving ICU admission, 82% surviving to hospital discharge, and fewer than 5% discharged to new nursing home care (4). Within the spectrum of frailty, the mildly frail have better outcomes than the moderately or severely frail, even in the oldest-old, and should not be excluded from ICU care. Moreover, as frailty has never been validated for ICU triaging in COVID-19 or related purposes, there is a need to establish strict criterion and construct validity for critically ill patients and generalisability of a score derived from non-critically ill patients in the chronic disease setting towards the critically ill (5). As healthcare systems become less overwhelmed with flattening of the epidemic curve, this affords an ideal window of opportunity to conduct validation studies of composite predictive models which incorporate frailty along with consistent predictors of poor outcomes in older adults admitted to the ICU such as age, comorbidities, disability and severity of illness (5). Forward conversations Achieving consensus on goals of care Amalgamating information from frailty assessments with patients’ antecedent wishes will enable physicians to recommend goal-concordant care. This highlights the importance of early Advanced Care Planning (ACP) discussions to understand patient’s preferences and therapeutic goals. Pre-COVID, these dialogues have been fairly opportunistic, as well as confined to patients with advanced illnesses or the acutely ill. Knowing that the current pandemic will be protracted, efforts should be streamlined towards engaging frail patients upstream while they are well. These forward conversations are especially salient for severely frail patients (including persons with advanced dementia) who are not likely to benefit from ICU care. Leaving decisions till crisis occurs would mean patients may lose their opportunity of exercising their autonomy to delirium, as well as risking impulsive decisions from distressed surrogates under time and situational pressure. Conclusion Hubbard et al. recommend that frailty screening tools should not be used in isolation but instead, are implemented as part of a person-centred approach to assessment in older adults that takes account of three key biomedical factors: severity of the presenting acute illness, the likelihood of medical interventions being successful and the degree of frailty (6). Our 3F approach presents a conceptual framework in a clinically sound and ethical manner that considers the strength and limitations of frailty assessment in determining its role in critical care decisions for older adults during the COVID-19 pandemic. Indeed, until we can meaningfully determine the exact contribution of frailty to adverse outcomes in critically ill older adults, frailty is better used as part of a multi-pronged assessment to assist prognostication and to guide meaningful conversations on goals of care i.e. to set goals of care rather than shift the goalpost of care.

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          Most cited references2

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          Frailty in very old critically ill patients in Australia and New Zealand: a population‐based cohort study

          To explore associations between frailty (Clinical Frailty Scale score of 5 or more) in very old patients in intensive care units (ICUs) and their clinical outcomes (mortality, discharge destination).
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            Translating the Science of Frailty in Singapore: Results from the National Frailty Consensus Discussion.

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              Author and article information

              Contributors
              raphael_lee@whc.sg
              Journal
              J Frailty Aging
              J Frailty Aging
              The Journal of Frailty & Aging
              Springer International Publishing (Cham )
              2260-1341
              2273-4309
              2 September 2020
              : 1-2
              Affiliations
              [1 ]GRID grid.240988.f, Department of Palliative Medicine, , Tan Tock Seng Hospital, ; Singapore, Singapore
              [2 ]GRID grid.240988.f, Institute of Geriatrics and Active Ageing, , Tan Tock Seng Hospital, ; Singapore, Singapore
              [3 ]GRID grid.240988.f, Department of Geriatric Medicine, , Tan Tock Seng Hospital, ; Singapore, Singapore
              [4 ]Department of Geriatric Medicine, Woodlands Health Campus, Singapore, Singapore
              [5 ]GRID grid.240988.f, Tan Tock Seng Hospital, ; Annex 2 Level 3, 11 Jalan Tan Tock Seng, Novena, Singapore, 308433 Singapore
              Article
              46
              10.14283/jfa.2020.46
              7463103
              eb91d153-81a3-44f8-bd2e-0d48a20aad9c
              © Serdi and Springer Nature Switzerland AG 2020

              This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

              History
              : 15 June 2020
              : 23 June 2020
              Categories
              Letter to the Editor

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