Auger Radiopharmaceutical Therapy Targeting Prostate-Specific Membrane Antigen.

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Abstract

Auger electron emitters such as (125)I have a high linear energy transfer and short range of emission (<10 μm), making them suitable for treating micrometastases while sparing normal tissues. We used a highly specific small molecule targeting the prostate-specific membrane antigen (PSMA) to deliver (125)I to prostate cancer cells.

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Journal

Journal ID (iso-abbrev): J. Nucl. Med.

Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine

ISSN (Electronic): 1535-5667

ISSN (Print): 0161-5505

Publication date (Electronic): Sep 2015

Volume: 56

Issue: 9

Affiliations

[1 ] Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, Maryland; and akiess1@jhmi.edu.

[2 ] Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, Maryland.

[3 ] Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, Maryland; and.

[4 ] Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, Maryland; and Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, Maryland.

Article

Publisher Item ID: jnumed.115.155929 Mid ID: NIHMS728724

DOI: 10.2967/jnumed.115.155929

PMC ID: 4634552

PubMed ID: 26182968

SO-VID: eb9733ad-08e5-479a-83db-e9d5799a9132

History

Keywords: Auger,PSMA,iodine,prostate cancer,radiopharmaceutical therapy,radiotherapy

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Keywords: Auger, PSMA, iodine, prostate cancer, radiopharmaceutical therapy, radiotherapy

Auger Radiopharmaceutical Therapy Targeting Prostate-Specific Membrane Antigen.

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