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      The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel.

      Science (New York, N.Y.)

      Transfection, Animals, metabolism, genetics, TRPV Cation Channels, Sodium, Rabbits, Protein Transport, Patch-Clamp Techniques, Mutation, Mice, Inbred C57BL, Mice, Membrane Proteins, cytology, Kidney, Hydrolysis, Humans, Glycosylation, antagonists & inhibitors, Glucuronidase, Cells, Cultured, Cell Membrane, Cell Line, Calcium Channels, Calcium

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          Abstract

          Blood calcium concentration is maintained within a narrow range despite large variations in dietary input and body demand. The Transient Receptor Potential ion channel TRPV5 has been implicated in this process. We report here that TRPV5 is stimulated by the mammalian hormone klotho. Klotho, a beta-glucuronidase, hydrolyzes extracellular sugar residues on TRPV5, entrapping the channel in the plasma membrane. This maintains durable calcium channel activity and membrane calcium permeability in kidney. Thus, klotho activates a cell surface channel by hydrolysis of its extracellular N-linked oligosaccharides.

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          Journal
          10.1126/science.1114245
          16239475

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