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      Biochemical Effects of Treatment with Oral Contraceptive Steroids on the Dopaminergic System of the Rat

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          Abstract

          The effects of acute and chronic administration of a combination of lynestrenol-mestranol, a widely employed contraceptive medication, on the dopaminergic system of the rat forebrain and striatum were investigated to better understand the biochemical basis of the neurological side-effects of steroid contraceptive drugs (SCDs). Both acute and chronic treatment increased the disappearance rate of striatal dopamine (DA) after synthesis blockade with α-methyl-p-tyrosine ( α-MpT). Moreover, the conversion of <sup>3</sup>H-tyrosine (<sup>3</sup>H-T) into <sup>3</sup>H-DA was increased in the forebrain and striatum after chronic administration of this steroid combination. In the same animals, the utilization of tyrosine (T) is increased.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1976
          1976
          25 March 2008
          : 22
          : 4
          : 343-351
          Affiliations
          Istituto di Ricerche Farmacologiche ‘Mario Negri’, Milan
          Article
          122643 Neuroendocrinology 1976;22:343–351
          10.1159/000122643
          1030500
          © 1976 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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          Pages: 9
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