Regio- and Enantioselective Aminofluorination of Alkenes

Feige, Pascal; Kong, Wangqing; Nevado, Cristina Rodríguez; de Haro, Teresa

doi:10.1002/anie.201208471

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Regio- and Enantioselective Aminofluorination of Alkenes

Author(s): Wangqing Kong , Pascal Feige , Teresa de Haro , Cristina Nevado

Publication date Created: February 25 2013

Publication date (Print): February 25 2013

Journal: Angewandte Chemie International Edition

Publisher: Wiley-Blackwell

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Fluorine in medicinal chemistry.

Sophie Purser, Peter R. Moore, Steve Swallow … (2008)

It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.