Petrolatum: Barrier repair and antimicrobial responses underlying this "inert" moisturizer.

Czarnowicki, Tali; Malajian, Dana; Khattri, Saakshi; Correa da Rosa, Joel; Dutt, Riana; Finney, Robert; Dhingra, Nikhil; Xiangyu, Peng; Xu, Hui; Estrada, Yeriel D; Zheng, Xiuzhong; Gilleaudeau, Patricia; Sullivan-Whalen, Mary; Suárez-Fariñas, Mayte; Shemer, Avner; Krueger, James G.; Guttman-Yassky, Emma

doi:10.1016/j.jaci.2015.08.013

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Petrolatum: Barrier repair and antimicrobial responses underlying this "inert" moisturizer.

Author(s): Tali Czarnowicki, Dana Malajian, Saakshi Khattri, Joel Correa da Rosa, Riana Dutt, Robert Finney, Nikhil Dhingra, Peng Xiangyu, Hui Xu, Yeriel D Estrada, Xiuzhong Zheng, Patricia Gilleaudeau, Mary Sullivan-Whalen, Mayte Suárez-Fariñas, Avner Shemer, James G. Krueger, Emma Guttman-Yassky

Publication date: 2016-04-01

Journal: The Journal of Allergy and Clinical Immunology

Publisher: Elsevier BV

Keywords: antimicrobial peptides, Petrolatum, atopic dermatitis, barrier, innate immunity, moisturizer, occlusion, patch tests, skin surgeries

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Abstract

Petrolatum is a common moisturizer often used in the prevention of skin infections after ambulatory surgeries and as a maintenance therapy of atopic dermatitis (AD). However, the molecular responses induced by petrolatum in the skin have never been assessed.