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      Definition and Antagonism of Histamine H2-receptors

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      Nature

      Springer Nature

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          Some quantitative uses of drug antagonists.

          Various applications of pA(x) measurements are discussed based on the hypothesis that drugs and drug antagonists compete for receptors according to the mass law. Examples are given illustrating the use of pA(x) measurements to identify agonists which act on the same receptors and to compare the receptors of different tissues. Tests of competitive and noncompetitive antagonism are considered in relation to the antagonisms acetylcholine-atropine, histamine-atropine and acetylcholine-cinchonidine. A new measure, pA(h), is introduced to express the activity of unsurmountable antagonists.
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            Gastric Secretion in Dogs Treated with Histamine Antagonist, Thymoxyethyldiethylamine

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              THE ANTIHISTAMINE SUBSTANCE 2786 R.P.

               J. GRAHAM,  P Dews (1946)
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                Author and article information

                Journal
                Nature
                Nature
                Springer Nature
                0028-0836
                1476-4687
                April 1972
                April 1972
                : 236
                : 5347
                : 385-390
                Article
                10.1038/236385a0
                © 1972

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