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      SWI/SNF recruitment to a DNA double-strand break by the NuA4 and Gcn5 histone acetyltransferases.

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          Abstract

          The DNA damage response to double-strand breaks (DSBs) is critical for cellular viability. Recent work has shown that a host of chromatin regulators are recruited to a DSB, and that they are important for the DNA damage response. However, the functional relationships between different chromatin regulators at DSBs remain unclear. Here we describe a conserved functional interaction among the chromatin remodeling enzyme, SWI/SNF, the NuA4 and Gcn5 histone acetyltransferases, and phosphorylation of histone H2A.X (γH2AX). Specifically, we find that the NuA4 and Gcn5 enzymes are both required for the robust recruitment of SWI/SNF to a DSB, which in turn promotes the phosphorylation of H2A.X.

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          Author and article information

          Journal
          DNA Repair (Amst.)
          DNA repair
          Elsevier BV
          1568-7856
          1568-7856
          Jun 2015
          : 30
          Affiliations
          [1 ] Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01606, USA.
          [2 ] Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01606, USA. Electronic address: Craig.Peterson@umassmed.edu.
          Article
          S1568-7864(15)00071-3 NIHMS681944
          10.1016/j.dnarep.2015.03.006
          4425604
          25869823
          ebc0ca65-8cff-454f-80ad-1a64813e4416
          History

          Chromatin,Gcn5,Histone acetyltransferase,Homologous recombination,NuA4,SWI/SNF

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