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      The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

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      Cell

      Elsevier BV

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          Abstract

          Notch signaling regulates many aspects of metazoan development and tissue renewal. Accordingly, the misregulation or loss of Notch signaling underlies a wide range of human disorders, from developmental syndromes to adult-onset diseases and cancer. Notch signaling is remarkably robust in most tissues even though each Notch molecule is irreversibly activated by proteolysis and signals only once without amplification by secondary messenger cascades. In this Review, we highlight recent studies in Notch signaling that reveal new molecular details about the regulation of ligand-mediated receptor activation, receptor proteolysis, and target selection.

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          Author and article information

          Journal
          Cell
          Cell
          Elsevier BV
          00928674
          April 2009
          April 2009
          : 137
          : 2
          : 216-233
          Article
          10.1016/j.cell.2009.03.045
          2827930
          19379690
          © 2009

          https://www.elsevier.com/tdm/userlicense/1.0/

          https://www.elsevier.com/open-access/userlicense/1.0/

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