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      Association of Interleukin-1 Receptor Antagonist Gene Polymorphism with IgA Nephropathy

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          Abstract

          It is evident that cytokines play an important role in the pathogenesis as well as disease progression of IgA nephropathy (IgAN). Several gene polymorphisms of the pertinent cytokines have an influence on the level of cytokine production. Interleukin-1 receptor antagonist (IL-1ra) gene polymorphism has been found to affect disease susceptibility and activity in several inflammatory diseases. In the present study, we analyzed polymorphism of the variable number tandem repeat (VNTR) of IL-1ra in patients diagnosed as having IgAN (n = 106) and normal controls (n = 74). The allele frequency of IL-1ra polymorphism in IgAN patients was not statistically different from that of the control group. There was no significant difference in the carriage rate of the two-repeat allele (IL1RN*2) between IgAN patients and the control group (8.5 vs. 6.8%). The carriage rate of IL1RN*2 was significantly higher in IgAN patients with severe proteinuria (≧1.6 g/day) or increased serum creatinine level (≧2.0 mg/dl; p < 0.05). Furthermore, the carriage rate of IL1RN*2 was significantly higher in patients with severe mesangial cell proliferation (p < 0.01). Our results suggest that IL-1ra polymorphisms are not associated with the development of IgAN in Japanese patients but the presence of IL1RN*2 may be associated with increased disease activity.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          2002
          August 2002
          15 July 2002
          : 91
          : 4
          : 744-746
          Affiliations
          First Department of Internal Medicine, Nara Medical University, Nara, Japan
          Article
          65040 Nephron 2002;91:744–746
          10.1159/000065040
          12138282
          © 2002 S. Karger AG, Basel

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          Page count
          Tables: 2, References: 10, Pages: 3
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          Self URI (application/pdf): https://www.karger.com/Article/Pdf/65040
          Categories
          Short Communication

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