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      Optical Diagnostic Based on Functionalized Gold Nanoparticles

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          Au nanoparticles (NPs) possess unique physicochemical and optical properties, showing great potential in biomedical applications. Diagnostic spectroscopy utilizing varied Au NPs has become a precision tool of in vitro and in vivo diagnostic for cancer and other specific diseases. In this review, we tried to comprehensively introduce the remarkable optical properties of Au NPs, including localized surfaces plasmon resonance (LSPR), surface-enhanced Raman scattering (SERS), and metal-enhanced fluorescence (MEF). Then, we highlighted the excellent works using Au NPs for optical diagnostic applications. Ultimately, the challenges and future perspective of using Au NPs for optical diagnostic were discussed.

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          Most cited references 124

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            Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity.

            This critical review provides an overall survey of the basic concepts and up-to-date literature results concerning the very promising use of gold nanoparticles (AuNPs) for medicinal applications. It includes AuNP synthesis, assembly and conjugation with biological and biocompatible ligands, plasmon-based labeling and imaging, optical and electrochemical sensing, diagnostics, therapy (drug vectorization and DNA/gene delivery) for various diseases, in particular cancer (also Alzheimer, HIV, hepatitis, tuberculosis, arthritis, diabetes) and the essential in vitro and in vivo toxicity. It will interest the medicine, chemistry, spectroscopy, biochemistry, biophysics and nanoscience communities (211 references).
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              Why gold nanoparticles are more precious than pretty gold: noble metal surface plasmon resonance and its enhancement of the radiative and nonradiative properties of nanocrystals of different shapes.

              This tutorial review presents an introduction to the field of noble metal nanoparticles and their current applications. The origin of the surface plasmon resonance and synthesis procedures are described. A number of applications are presented that take advantage of the electromagnetic field enhancement of the radiative properties of noble metal nanoparticles resulting from the surface plasmon oscillations.

                Author and article information

                [1 ]School of Traditional Chinese Medicine Resources, Guangdong Pharmaceutical University, Guangzhou 510006, China
                [2 ]School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China
                [3 ]Instrumentation and Service Center for Physical Sciences, School of Science, Westlake University, 18 Shilongshan Road, Xihu District, Hangzhou 310064, China
                [4 ]School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China
                Author notes
                [* ]Correspondence: zhouzd@ (Z.Z.) chenzhong@ (Z.C.); Tel.: +86-188-2605-0359 (Z.Z.); +86-189-9838-2617 (Z.C.)
                Int J Mol Sci
                Int J Mol Sci
                International Journal of Molecular Sciences
                05 September 2019
                September 2019
                : 20
                : 18
                31491861 6770972 10.3390/ijms20184346 ijms-20-04346
                © 2019 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (


                Molecular biology

                optical diagnostic, mef, sers, lspr, plasmonic, gold nanoparticles


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