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      Optical Diagnostic Based on Functionalized Gold Nanoparticles

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          Abstract

          Au nanoparticles (NPs) possess unique physicochemical and optical properties, showing great potential in biomedical applications. Diagnostic spectroscopy utilizing varied Au NPs has become a precision tool of in vitro and in vivo diagnostic for cancer and other specific diseases. In this review, we tried to comprehensively introduce the remarkable optical properties of Au NPs, including localized surfaces plasmon resonance (LSPR), surface-enhanced Raman scattering (SERS), and metal-enhanced fluorescence (MEF). Then, we highlighted the excellent works using Au NPs for optical diagnostic applications. Ultimately, the challenges and future perspective of using Au NPs for optical diagnostic were discussed.

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          Raman spectra of pyridine adsorbed at a silver electrode

          Roy M Fleischmann, P.J. Hendra, A.J. McQuillan (1974)
          Article 0 comments Cited 439 times – based on 0 reviews     Review now
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            Physical Principles of Nanoparticle Cellular Endocytosis.

            Sulin Zhang, Huajian Gao, Gang Bao (2015)
            This review article focuses on the physiochemical mechanisms underlying nanoparticle uptake into cells. When nanoparticles are in close vicinity to a cell, the interactions between the nanoparticles and the cell membrane generate forces from different origins. This leads to the membrane wrapping of the nanoparticles followed by cellular uptake. This article discusses how the kinetics, energetics, and forces are related to these interactions and dependent on the size, shape, and stiffness of nanoparticles, the biomechanical properties of the cell membrane, as well as the local environment of the cells. The discussed fundamental principles of the physiochemical causes for nanoparticle-cell interaction may guide new studies of nanoparticle endocytosis and lead to better strategies to design nanoparticle-based approaches for biomedical applications.
            Article 0 comments Cited 265 times – based on 0 reviews     Review now
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              Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity.

              Elodie Boisselier, Didier Astruc (2009)
              This critical review provides an overall survey of the basic concepts and up-to-date literature results concerning the very promising use of gold nanoparticles (AuNPs) for medicinal applications. It includes AuNP synthesis, assembly and conjugation with biological and biocompatible ligands, plasmon-based labeling and imaging, optical and electrochemical sensing, diagnostics, therapy (drug vectorization and DNA/gene delivery) for various diseases, in particular cancer (also Alzheimer, HIV, hepatitis, tuberculosis, arthritis, diabetes) and the essential in vitro and in vivo toxicity. It will interest the medicine, chemistry, spectroscopy, biochemistry, biophysics and nanoscience communities (211 references).
              Article 0 comments Cited 257 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Int J Mol Sci
                Journal ID (iso-abbrev): Int J Mol Sci
                Journal ID (publisher-id): ijms
                Title: International Journal of Molecular Sciences
                Publisher: MDPI
                ISSN (Electronic): 1422-0067
                Publication date (Electronic): 05 September 2019
                Publication date Collection: September 2019
                Volume: 20
                Issue: 18
                Electronic Location Identifier: 4346
                Affiliations
                [1 ]School of Traditional Chinese Medicine Resources, Guangdong Pharmaceutical University, Guangzhou 510006, China
                [2 ]School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China
                [3 ]Instrumentation and Service Center for Physical Sciences, School of Science, Westlake University, 18 Shilongshan Road, Xihu District, Hangzhou 310064, China
                [4 ]School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China
                Author notes
                [* ]Correspondence: zhouzd@ 123456gdpu.edu.cn (Z.Z.) chenzhong@ 123456mail.sysu.edu.cn (Z.C.); Tel.: +86-188-2605-0359 (Z.Z.); +86-189-9838-2617 (Z.C.)
                Author information
                https://orcid.org/0000-0001-6641-751X
                Article
                Publisher ID: ijms-20-04346
                DOI: 10.3390/ijms20184346
                PMC ID: 6770972
                PubMed ID: 31491861
                SO-VID: ebd3e324-f9f4-4762-a79a-250d6fdcd745
                Copyright © © 2019 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 31 July 2019
                Date accepted : 03 September 2019
                Categories
                Subject: Review

                ScienceOpen disciplines: Molecular biology
                Keywords: gold nanoparticles,plasmonic,lspr,sers,mef,optical diagnostic
                Data availability:
                ScienceOpen disciplines: Molecular biology
                Keywords: gold nanoparticles, plasmonic, lspr, sers, mef, optical diagnostic

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