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      • Record: found
      • Abstract: found
      • Article: found

      Ultrastructural Changes in the Rat Photoreceptor Inner Segment During Experimental Chloroquine Retinopathy

      research-article
      Author(s): ,
      Publication date (Electronic):
      Journal: Ophthalmic Research
      Publisher: S. Karger AG
      Keywords: Retina, Chloroquine, Photoreceptors, Rat, Electron microscopy, Experimental Retinopathy

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          Abstract

          Hooded rats were given chloroquine phosphate (Aralen) over an eight month period during which regular indirect ophthalmoscopic examinations were performed. When retinal or anterior ocular changes were observed in poisoned rats, retinas were prepared for electron microscopy. Significant ultrastructural changes were localized in the inner segments of the receptor cells, where mitochondrial swelling, disappearance of theciliary process and disorganization of the endoplasmic reticulum were observed. Observations were consistent with previous clinical, light microscopic and electroretinographic findings.

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          Author and article information

          Journal
          Journal ID (publisher-id): ORE
          Journal ID (nlm-ta): Ophthalmic Res
          Journal ID (doi): 10.1159/issn.0030-3747
          Title: Ophthalmic Research
          Publisher: S. Karger AG
          ISSN (Print): 0030-3747
          ISSN (Electronic): 1423-0259
          Publication date Subscription-year: 1970
          Publication date (Print): 1970
          Publication date (Electronic): 27 November 2009
          Volume: 1
          Issue: 3
          Pages: 140-148
          Affiliations
          Laboratory of Cellular and Molecular Biology, Institute for Research In Vision, and Department of Ophthalmology, Ohio State University, Columbus, Ohio
          Article
          Publisher ID: 264511 Other ID: Ophthal Res 1970;1:140–148
          DOI: 10.1159/000264511
          SO-VID: ebd8baf2-eca0-4e3d-aef4-9e98d57cb012
          Copyright © © 1970 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Page count
          Pages: 9
          Categories
          Subject: Paper

          ScienceOpen disciplines: Vision sciences,Ophthalmology & Optometry,Pathology
          Keywords: Retina,Rat,Electron microscopy,Experimental Retinopathy,Chloroquine,Photoreceptors
          Data availability:
          ScienceOpen disciplines: Vision sciences, Ophthalmology & Optometry, Pathology
          Keywords: Retina, Rat, Electron microscopy, Experimental Retinopathy, Chloroquine, Photoreceptors

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