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      Ultrastructural Changes in the Rat Photoreceptor Inner Segment During Experimental Chloroquine Retinopathy


      Ophthalmic Research

      S. Karger AG

      Retina, Chloroquine, Photoreceptors, Rat, Electron microscopy, Experimental Retinopathy

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          Hooded rats were given chloroquine phosphate (Aralen) over an eight month period during which regular indirect ophthalmoscopic examinations were performed. When retinal or anterior ocular changes were observed in poisoned rats, retinas were prepared for electron microscopy. Significant ultrastructural changes were localized in the inner segments of the receptor cells, where mitochondrial swelling, disappearance of theciliary process and disorganization of the endoplasmic reticulum were observed. Observations were consistent with previous clinical, light microscopic and electroretinographic findings.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          27 November 2009
          : 1
          : 3
          : 140-148
          Laboratory of Cellular and Molecular Biology, Institute for Research In Vision, and Department of Ophthalmology, Ohio State University, Columbus, Ohio
          264511 Ophthal Res 1970;1:140–148
          © 1970 S. Karger AG, Basel

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          Page count
          Pages: 9


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