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      Development of anticancer drugs based on the hallmarks of tumor cells.

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          Abstract

          Cancer remains a public health problem with a high unmet medical demand. However, in recent decades, the knowledge of several functional molecular and biological traits that distinguish tumor cells from normal cells, known as the hallmarks of cancer as described by Hannahan and Weinberg, has led to new and modern therapeutic approaches against this disease. Most cancer drugs are deliberately developed for specific molecular targets that involve these hallmarks. In this review, we address the currently available cancer drugs and development of new drugs from the perspective of their interaction with these hallmarks as well as the pathways and mechanisms involved.

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          Affiliations
          [1 ] Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Circuito Escolar, Cd. Universitaria, Coyoacán, 04510, México, D.F., México.
          Journal
          Tumour Biol.
          Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
          Springer Nature
          1423-0380
          1010-4283
          May 2014
          : 35
          : 5
          10.1007/s13277-014-1649-y
          24470139

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