Investigation of Serum Oxidized Low-Density Lipoprotein IgG Levels in Patients with Angiographically Defined Coronary Artery Disease

Abstract

It has been suggested that antioxidized low-density lipoprotein (anti-oxLDL) antibodies play a role in the pathogenesis of atherosclerosis. The aim of this study was to measure serum ox-LDL IgG levels in 31 patients with angiographically defined coronary artery disease (CAD) (≥50% stenosis in at least one major coronary artery; CAD ⁺ group) and compare these levels with those of 32 subjects with <50% coronary stenosis (CAD ⁻ group) and 24 healthy age- and sex-matched controls using ELISA. We did not find any significant difference between CAD ⁺, CAD ⁻, and control groups in regard to oxLDL IgG levels ( P = 0.83). Serum oxLDL IgG levels did not differ between 1VD (one vessel disease), 2VD (2 vessels disease), and 3VD (3 vessels disease) subgroups of CAD ⁺ patients ( P = 0.20). Serum anti-oxLDL titers were only significantly correlated with LDL-C in the CAD ⁺ group ( P < 0.05) and waist and hip circumference ( P < 0.05 and P < 0.01, resp.) in the CAD ⁻ group. In stepwise regression analysis, none of the conventional cardiovascular risk factors was associated with serum ox-LDL IgG levels. The present results suggest that serum levels of ox-LDL IgG are neither associated with the presence and severity of CAD nor with the conventional cardiovascular risk factors.

Journal

Journal ID (nlm-ta): Int J Vasc Med

Journal ID (iso-abbrev): Int J Vasc Med

Journal ID (publisher-id): IJVM

Title: International Journal of Vascular Medicine

Publisher: Hindawi Publishing Corporation

ISSN (Print): 2090-2824

ISSN (Electronic): 2090-2832

Publication date (Print): 2014

Publication date (Electronic): 3 February 2014

Volume: 2014

Affiliations

¹Cardiovascular Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

²Department of Cardiology, Mashhad University of Medical Sciences, Mashhad, Iran

³Student Research Committee, Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

⁴Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran

⁵Health Sciences Research Center, Department of Biostatistics and Epidemiology, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran

⁶Department of Clinical Biochemistry, Tehran University of Medical Sciences, Tehran, Iran

⁷Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Author notes

*Majid Ghayour-Mobarhan: ghayourm@ 123456mums.ac.ir

Academic Editor: Karlheinz Peter

Article

DOI: 10.1155/2014/845960

PMC ID: 3930021

Copyright statement: Copyright © 2014 Mohsen Moohebati et al.

License:

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Categories

Subject: Research Article