Real-world incidence of breakthrough COVID-19 hospitalization after vaccination versus natural infection in a large, local, empaneled primary care population using time-to-event analysis

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Abstract

We followed 106,349 primary care patients for 22,385,309 person-days across 21 calendar months. There were 69 breakthrough COVID-19 hospitalizations: 65/102,613(0.06%) among fully vaccinated, 3/11,047(0.03%) among those previously infected, and 1/7,313(0.01%) among those with both statuses. This data gives primary care providers real-world context regarding breakthrough COVID-19 hospitalization risk.

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Author and article information

Journal

Journal ID (nlm-ta): Clin Infect Dis

Journal ID (iso-abbrev): Clin Infect Dis

Journal ID (publisher-id): cid

Title: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America

Publisher: Oxford University Press (US )

ISSN (Print): 1058-4838

ISSN (Electronic): 1537-6591

Publication date (Electronic): 05 March 2022

Publication date PMC-release: 05 March 2022

Electronic Location Identifier: ciac186

Affiliations

[1 ] Division of Health Care Delivery Research, Robert D. and Patricia E, Kern Center for the Science of Health Care Delivery , Mayo Clinic, Jacksonville, FL, USA

[2 ] Division of Data Science, Robert D. and Patricia E, Kern Center for the Science of Health Care Delivery , Mayo Clinic, Rochester, MN, USA

[3 ] Division of Infectious Diseases, Mayo Clinic, Rochester , MN, USA

Author notes

Corresponding Author: Ben Pollock, PhD, MSPH, Assistant Professor of Health Services Research, Mayo Clinic – Stabile 750N, 4500 San Pablo Road, Jacksonville, FL 32224, Email: Pollock.Benjamin@ 123456Mayo.Edu

Author information

Benjamin D Pollock https://orcid.org/0000-0003-4544-3158

Article

Publisher ID: ciac186

DOI: 10.1093/cid/ciac186

PMC ID: 8903437

PubMed ID: 35247261

SO-VID: ec065d14-8213-4339-a2e3-aabd233ba853

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