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Nitric oxide for inhalation in the acute treatment of sickle cell pain crisis: a randomized controlled trial.
Mark T Gladwin
1 ,
Gregory J Kato ,
Debra Weiner ,
Onyinye C Onyekwere ,
Carlton Dampier ,
Lewis Hsu ,
R Ward Hagar ,
Thomas Howard ,
Rachelle Nuss ,
Maureen M Okam ,
Carole K Tremonti ,
Brian Berman ,
Anthony Villella ,
Lakshmanan Krishnamurti ,
Sophie Lanzkron ,
Oswaldo Castro ,
Victor R Gordeuk ,
Wynona A Coles ,
Marlene Peters-Lawrence ,
James Nichols ,
Mary K Hall ,
Mariana Hildesheim ,
William C Blackwelder ,
James Baldassarre ,
James F Casella
Mar 02 2011
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Abstract
Inhaled nitric oxide has shown evidence of efficacy in mouse models of sickle cell disease (SCD), case series of patients with acute chest syndrome, and 2 small placebo-controlled trials for treatment of vaso-occlusive pain crisis (VOC).