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      Mycophenolate mofetil: safety and efficacy in the prophylaxis of acute kidney transplantation rejection

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          Abstract

          Mycophenolate mofetil (MMF), a prodrug of mycophenolic acid (MPA), is an inhibitor of inosine monophosphate dehydrogenase (IMPDH). It preferentially inhibits denovo pathway of guanosine nucleotide synthesis in T and B-lymphocytes and prevents their proliferation, thereby suppresses both cell mediated and humoral immune responses. Clinical trials in kidney transplant recipients have shown the efficacy of MMF in reducing the incidence and severity of acute rejection episodes. It also improves long term graft function as well as graft and patient survival in kidney transplant recipients. MMF is useful as a component of toxicity sparing regimens to reduce or avoid exposure of steroids or calcineurin inhibitor (CNI). Enteric-coated mycophenolate sodium (EC-MPS) can be used as an alternative immunosuppressive agent in kidney transplant recipients with efficacy and safety profile similar to MMF.

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          Author and article information

          Journal
          Ther Clin Risk Manag
          Therapeutics and Clinical Risk Management
          Therapeutics and Clinical Risk Management
          Dove Medical Press
          1176-6336
          1178-203X
          2009
          2009
          26 March 2009
          : 5
          : 139-149
          Affiliations
          [1 ]Department of Medicine, Mount Sinai Hospital, Chicago, USA;
          [2 ]Northwestern University–Feinberg School of Medicine, Chicago, USA
          Author notes
          Correspondence: Lorenzo Gallon, Northwestern University–Feinberg, School of Medicine, 320 E Superior, Avenue, Galter 17-200, Chicago, IL 60611, USA, Tel +1 312-695-4457, Fax +1 312-695-9194, Email l-gallon@ 123456northwestern.edu
          Article
          tcrm-5-0139
          2697521
          19436616
          © 2009 Dalal et al, publisher and licensee Dove Medical Press Ltd.

          This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

          Categories
          Review

          Medicine

          acute rejection, toxicity sparing, kidney transplantation, mycophenolate mofetil

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