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      Activated type 2 innate lymphoid cells regulate beige fat biogenesis.

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          Abstract

          Type 2 innate lymphoid cells (ILC2s), an innate source of the type 2 cytokines interleukin (IL)-5 and -13, participate in the maintenance of tissue homeostasis. Although type 2 immunity is critically important for mediating metabolic adaptations to environmental cold, the functions of ILC2s in beige or brown fat development are poorly defined. We report here that activation of ILC2s by IL-33 is sufficient to promote the growth of functional beige fat in thermoneutral mice. Mechanistically, ILC2 activation results in the proliferation of bipotential adipocyte precursors (APs) and their subsequent commitment to the beige fat lineage. Loss- and gain-of-function studies reveal that ILC2- and eosinophil-derived type 2 cytokines stimulate signaling via the IL-4Rα in PDGFRα(+) APs to promote beige fat biogenesis. Together, our results highlight a critical role for ILC2s and type 2 cytokines in the regulation of adipocyte precursor numbers and fate, and as a consequence, adipose tissue homeostasis. PAPERCLIP:

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          Author and article information

          Journal
          Cell
          Cell
          1097-4172
          0092-8674
          Jan 15 2015
          : 160
          : 1-2
          Affiliations
          [1 ] Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94158-9001, USA.
          [2 ] Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143-0795, USA.
          [3 ] Department of Medicine, University of California, San Francisco, CA 94143-0795, USA.
          [4 ] Department of Medicine, University of California, San Francisco, CA 94143-0795, USA; Department of Microbiology and Immunology, University of California, San Francisco, CA 94143-0795, USA; Howard Hughes Medical Institute, University of California, San Francisco, CA 94143-0795, USA.
          [5 ] Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94158-9001, USA; Departments of Physiology and Medicine, University of California San Francisco, San Francisco, CA 94158-9001, USA. Electronic address: ajay.chawla@ucsf.edu.
          Article
          S0092-8674(14)01581-5 NIHMS647465
          10.1016/j.cell.2014.12.011
          25543153
          Copyright © 2015 Elsevier Inc. All rights reserved.

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