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      Gastric emptying of a liquid nutrient meal in the critically ill: relationship between scintigraphic and carbon breath test measurement.

      Gut

      Young Adult, Adult, Aged, Aged, 80 and over, Breath Tests, methods, Carbon Dioxide, analysis, Carbon Radioisotopes, diagnostic use, Critical Illness, therapy, Enteral Nutrition, Exhalation, Female, Follow-Up Studies, Gastric Emptying, physiology, Gastroparesis, physiopathology, radionuclide imaging, Humans, Intensive Care Units, Male, Middle Aged, Prospective Studies, Stomach, Technetium Tc 99m Sulfur Colloid

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          Abstract

          It is assumed that delayed gastric emptying (GE) occurs frequently in critical illness; however, the prevalence of slow GE has not previously been assessed using scintigraphy. Furthermore, breath tests could potentially provide a convenient method of quantifying GE, but have not been validated in this setting. The aims of this study were to (i) determine the prevalence of delayed GE in unselected, critically ill patients and (ii) evaluate the relationships between GE as measured by scintigraphy and carbon breath test. Prospective observational study. Mixed medical/surgical intensive care unit. 25 unselected, mechanically ventilated patients (age 66 years (49-72); and 14 healthy subjects (age 62 years (19-84)). GE was measured using scintigraphy and (14)C-breath test. A test meal of 100 ml Ensure (standard liquid feed) labelled with (14)C octanoic acid and (99m)Technetium sulphur colloid was placed in the stomach via a nasogastric tube. Gastric 'meal' retention (scintigraphy) at 60, 120, 180 and 240 min, breath test t(50) (BTt(50)), and GE coefficient were determined. Of the 24 patients with scintigraphic data, GE was delayed at 120 min in 12 (50%). Breath tests correlated well with scintigraphy in both patients and healthy subjects (% retention at 120 min vs BTt(50); r(2)=0.57 healthy; r(2)=0.56 patients; p≤0.002 for both). GE of liquid nutrient is delayed in approximately 50% of critically ill patients. Breath tests correlate well with scintigraphy and are a valid method of GE measurement in this group.

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          Journal
          10.1136/gut.2010.227934
          21450697

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