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      Glucagon-like peptide 2 counteracts the mucosal damage and the neuropathy induced by chronic treatment with cisplatin in the mouse gastric fundus.

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          Abstract

          Glucagon-like peptide-2 (GLP-2) is a pleiotropic hormone synthesized and secreted by the enteroendocrine 'L' cells able to exert intestine-trophic and anti-inflammatory effects. The antineoplastic drug cisplatin causes gastrointestinal alterations with clinical symptoms (nausea and vomiting) that greatly affect the therapy compliance. Experimentally, it has been reported that chronic cisplatin treatment caused mucosal damage and enteric neuropathy in the rat colon.

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          Author and article information

          Journal
          Neurogastroenterol. Motil.
          Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
          Wiley-Blackwell
          1365-2982
          1350-1925
          Feb 2016
          : 28
          : 2
          Affiliations
          [1 ] Department of Experimental and Clinical Medicine, Histology and Embryology Research Unit, University of Florence, Florence, Italy.
          [2 ] Department of Experimental and Clinical Medicine, Section of Physiological Sciences, University of Florence, Florence, Italy.
          Article
          10.1111/nmo.12712
          26547262

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