M2-polarized tumor-associated macrophage infiltration of regional lymph nodes is associated with nodal lymphangiogenesis and occult nodal involvement in pN0 pancreatic cancer.

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Abstract

Tumor-associated macrophages (TAMs) are reportedly involved in lymphangiogenesis in primary tumors, playing a crucial role in lymphatic metastasis. Furthermore, nodal lymphangiogenesis precedes and promotes regional lymph node (RLN) metastasis. We investigated the relationship of M2-polarized TAM infiltration of the RLNs, nodal lymphangiogenesis, and occult nodal involvement in pN0 pancreatic cancer.

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Journal

Journal ID (iso-abbrev): Pancreas

Title: Pancreas

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1536-4828

ISSN (Print): 0885-3177

Publication date (Electronic): Jan 2013

Volume: 42

Issue: 1

Affiliations

[1 ] Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan. h-krhr@m3.kufm.kagoshima-u.ac.jp

Article

DOI: 10.1097/MPA.0b013e318254f2d1

PubMed ID: 22699204

SO-VID: ec3bfaf3-b099-406e-b365-fb6e68616428

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