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      DREADDs for Neuroscientists

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      Neuron

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          Abstract

          To understand brain function, it is essential that we discover how cellular signaling specifies normal and pathological brain function. In this regard, chemogenetic technologies represent valuable platforms for manipulating neuronal and non-neuronal signal transduction in a cell-type-specific fashion in freely moving animals. Designer Receptors Exclusively Activated by Designer Drugs (DREADD)-based chemogenetic tools are now commonly used by neuroscientists to identify the circuitry and cellular signals that specify behavior, perceptions, emotions, innate drives, and motor functions in species ranging from flies to nonhuman primates. Here I provide a primer on DREADDs highlighting key technical and conceptual considerations and identify challenges for chemogenetics going forward.

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          Author and article information

          Journal
          8809320
          1600
          Neuron
          Neuron
          Neuron
          0896-6273
          1097-4199
          29 January 2016
          17 February 2016
          17 February 2017
          : 89
          : 4
          : 683-694
          Affiliations
          [1 ]Department of Pharmacology, University of North Carolina Chapel Hill Medical School, Chapel Hill, NC 27514, USA
          Author notes
          Article
          PMC4759656 PMC4759656 4759656 nihpa754820
          10.1016/j.neuron.2016.01.040
          4759656
          26889809
          ec412e81-c9fa-4830-9ae8-461542fa4e73
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