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Versican and fibrillin-1 form a major hyaluronan-binding complex in the ciliary body.
Akiko Ohno-Jinno
1 ,
Zenzo Isogai ,
Masahiko Yoneda ,
Kenji Kasai ,
Osamu Miyaishi ,
Yoko Inoue ,
Takuya Kataoka ,
Jing-Song Zhao ,
Huili Li ,
Masayuki Takeyama ,
Douglas R Keene ,
Lynn Y Sakai ,
Koji Kimata ,
Masayoshi Iwaki ,
Masahiro Zako
Jul 2008
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Abstract
In this study, biochemistry, molecular biology, immunohistochemistry, and electron microscopy techniques were used to examine whether versican, which is known to bind fibrillin-1, interacts with fibrillin-1 in the ciliary body and vitreous, and whether the versican in this complex binds to hyaluronan.