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      Effects of a Met-Enkephalin Analogue and Naloxone Infusion on Anterior Pituitary Hormone Secretion in Acromegaly

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          The effect of a long-acting analogue of Met-enkephalin (Damme) and naloxone on anterior pituitary hormone secretion has been investigated in 14 acromegalic patients. Damme produced a progressive fall in circulating LH and cortisol and stimulated prolactin release in normoprolactinaemic patients. Naloxone infusion significantly stimulated gonadotrophin and cortisol secretion without modifying basal prolactin release both in normo- and hyperprolactinaemic patients. GH levels remained unchanged during naloxone and Damme infusion. The data suggest that endogenous opiate receptors do not play a major role in modulating GH hypersecretion in acromegaly.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          25 November 2008
          : 15
          : 2
          : 88-98
          aDepartment of Internal Medicine, ISMI, Cattedra di Endocrinologia; bCattedra di Semeiotica Medica R, Genoa, Italia
          179438 Horm Res 1981;15:88–98
          © 1981 S. Karger AG, Basel

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          Pages: 11
          Original Paper


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