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      Ocular delivery of macromolecules

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      Journal of Controlled Release

      Elsevier BV

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          Abstract

          Biopharmaceuticals are making increasing impact on medicine, including treatment of indications in the eye. Macromolecular drugs are typically given by physician-administered invasive delivery methods, because non-invasive ocular delivery methods, such as eye drops, and systemic delivery, have low bioavailability and/or poor ocular targeting. There is a need to improve delivery of biopharmaceuticals to enable less-invasive delivery routes, less-frequent dosing through controlled-release drug delivery and improved drug targeting within the eye to increase efficacy and reduce side effects. This review discusses the barriers to drug delivery via various ophthalmic routes of administration in the context of macromolecule delivery and discusses efforts to develop controlled-release systems for delivery of biopharmaceuticals to the eye. The growing number of macromolecular therapies in the eye needs improved drug delivery methods that increase drug efficacy, safety and patient compliance.

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          Author and article information

          Journal
          Journal of Controlled Release
          Journal of Controlled Release
          Elsevier BV
          01683659
          September 2014
          September 2014
          : 190
          : 172-181
          Article
          10.1016/j.jconrel.2014.06.043
          4142116
          24998941
          © 2014

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