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      Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia.

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          Abstract

          Mononuclear phagocytes are highly plastic cells that assume diverse phenotypes in response to microenvironmental signals. The phenotype-specific roles of microglia/macrophages in ischemic brain injury are poorly understood. A comprehensive characterization of microglia/macrophage polarization after ischemia may advance our knowledge of poststroke damage/recovery.

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          Author and article information

          Journal
          Stroke
          Stroke
          Ovid Technologies (Wolters Kluwer Health)
          1524-4628
          0039-2499
          Nov 2012
          : 43
          : 11
          Affiliations
          [1 ] State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Fudan University, Shanghai, China. hux2@upmc.edu
          Article
          STROKEAHA.112.659656
          10.1161/STROKEAHA.112.659656
          22933588

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