7
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Hypogelsolinemia and Decrease in Blood Plasma Sphingosine-1-Phosphate in Patients Diagnosed with Severe Acute Pancreatitis

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background

          Acute pancreatitis (AP) is a frequent hospitalization cause of patients suffering from gastrointestinal disorders. Gelsolin has an ability to bind bioactive lipids including different sphingolipids engaged in inflammatory response. Importantly, hypogelsolinemia was observed in patients with different states of acute and chronic inflammation.

          Aims

          The aim of the present study was to assess the interplay of blood plasma gelsolin and blood plasma sphingosine-1-phosphate (S1P) concentration in patients diagnosed with acute pancreatitis.

          Materials and Methods

          To assess the concentration of gelsolin and S1P, immunoblotting and HPLC technique were employed, respectively. Additionally, the concentrations of amylase, lipase, C-reactive protein (CRP), procalcitonin (PCT) and the number of white blood cells (WBC) and platelet (PLT) were recorded.

          Results

          We found that both pGSN and S1P concentrations in the plasma of the AP patients were significantly lower (pGSN ~ 15–165 mg/L; S1P ~ 100–360 pmol/mL) when compared to the levels of pGSN and S1P in a control group (pGSN ~ 130–240 mg/L; S1P ~ 260–400 pmol/mL). Additionally, higher concentrations of CRP, WBC, amylase and lipase were associated with low level of gelsolin in the blood of AP patients. No correlations between the level of PCT and PLT with gelsolin concentration were noticed.

          Conclusion

          Plasma gelsolin and S1P levels decrease during severe acute pancreatitis. Simultaneous assessment of pGSN and S1P can be useful in development of more accurate diagnostic strategies for patients with severe acute pancreatitis.

          Related collections

          Most cited references45

          • Record: found
          • Abstract: found
          • Article: not found

          Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus.

          The Atlanta classification of acute pancreatitis enabled standardised reporting of research and aided communication between clinicians. Deficiencies identified and improved understanding of the disease make a revision necessary. A web-based consultation was undertaken in 2007 to ensure wide participation of pancreatologists. After an initial meeting, the Working Group sent a draft document to 11 national and international pancreatic associations. This working draft was forwarded to all members. Revisions were made in response to comments, and the web-based consultation was repeated three times. The final consensus was reviewed, and only statements based on published evidence were retained. The revised classification of acute pancreatitis identified two phases of the disease: early and late. Severity is classified as mild, moderate or severe. Mild acute pancreatitis, the most common form, has no organ failure, local or systemic complications and usually resolves in the first week. Moderately severe acute pancreatitis is defined by the presence of transient organ failure, local complications or exacerbation of co-morbid disease. Severe acute pancreatitis is defined by persistent organ failure, that is, organ failure >48 h. Local complications are peripancreatic fluid collections, pancreatic and peripancreatic necrosis (sterile or infected), pseudocyst and walled-off necrosis (sterile or infected). We present a standardised template for reporting CT images. This international, web-based consensus provides clear definitions to classify acute pancreatitis using easily identified clinical and radiologic criteria. The wide consultation among pancreatologists to reach this consensus should encourage widespread adoption.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Acute pancreatitis.

            Acute pancreatitis, an inflammatory disorder of the pancreas, is the leading cause of admission to hospital for gastrointestinal disorders in the USA and many other countries. Gallstones and alcohol misuse are long-established risk factors, but several new causes have emerged that, together with new aspects of pathophysiology, improve understanding of the disorder. As incidence (and admission rates) of acute pancreatitis increase, so does the demand for effective management. We review how to manage patients with acute pancreatitis, paying attention to diagnosis, differential diagnosis, complications, prognostic factors, treatment, and prevention of second attacks, and the possible transition from acute to chronic pancreatitis.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation.

              Sphingolipid signaling pathways have been implicated in many critical cellular events. Sphingosine-1-phosphate (SPP), a sphingolipid metabolite found in high concentrations in platelets and blood, stimulates members of the endothelial differentiation gene (Edg) family of G protein-coupled receptors and triggers diverse effects, including cell growth, survival, migration, and morphogenesis. To determine the in vivo functions of the SPP/Edg signaling pathway, we disrupted the Edg1 gene in mice. Edg1(-/-) mice exhibited embryonic hemorrhage leading to intrauterine death between E12.5 and E14.5. Vasculogenesis and angiogenesis appeared normal in the mutant embryos. However, vascular maturation was incomplete due to a deficiency of vascular smooth muscle cells/pericytes. We also show that Edg-1 mediates an SPP-induced migration response that is defective in mutant cells due to an inability to activate the small GTPase, Rac. Our data reveal Edg-1 to be the first G protein-coupled receptor required for blood vessel formation and show that sphingolipid signaling is essential during mammalian development.
                Bookmark

                Author and article information

                Contributors
                buckirobert@gmail.com
                Journal
                Dig Dis Sci
                Dig Dis Sci
                Digestive Diseases and Sciences
                Springer US (New York )
                0163-2116
                1573-2568
                23 February 2021
                23 February 2021
                2022
                : 67
                : 2
                : 536-545
                Affiliations
                [1 ]Holy Cross Oncology Center of Kielce, Artwińskiego 3, 25-734 Kielce, Poland
                [2 ]GRID grid.419032.d, ISNI 0000 0001 1339 8589, Department of Hematology, , Institute of Hematology and Transfusion Medicine, ; Indiry Gandhi 14, 02-776 Warsaw, Poland
                [3 ]GRID grid.48324.39, ISNI 0000000122482838, Department of Medical Microbiology and Nanobiomedical Engineering, , Medical University of Białystok, ; Mickiewicza 2C, 15-222 Białystok, Poland
                [4 ]GRID grid.411821.f, ISNI 0000 0001 2292 9126, Institute of Medical Science, Collegium Medicum, , Jan Kochanowski University of Kielce, ; IX Wieków Kielc 19A, 25-317 Kielce, Poland
                [5 ]GRID grid.48324.39, ISNI 0000000122482838, Department of Gastroenterology and Internal Medicine, , Medical University of Bialystok, ; Skłodowskiej-Curie 24A, 15-276 Bialystok, Poland
                [6 ]GRID grid.48324.39, ISNI 0000000122482838, Department of Hygiene, Epidemiology and Ergonomics, , Medical University of Bialystok, ; Mickiewicza 2C, 15-222 Bialystok, Poland
                Author information
                http://orcid.org/0000-0001-7664-9226
                Article
                6865
                10.1007/s10620-021-06865-y
                8885474
                33620599
                ec8e8dbd-27d1-487a-a90b-bc536f8b0dfe
                © The Author(s) 2021

                Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

                History
                : 25 April 2020
                : 20 January 2021
                Funding
                Funded by: FundRef http://dx.doi.org/10.13039/501100004281, Narodowe Centrum Nauki;
                Award ID: UMO-2015/17/B/NZ6/03473
                Award Recipient :
                Categories
                Original Article
                Custom metadata
                © Springer Science+Business Media, LLC, part of Springer Nature 2022

                Gastroenterology & Hepatology
                gelsolin,sphingosine-1-phosphate,acute pancreatitis
                Gastroenterology & Hepatology
                gelsolin, sphingosine-1-phosphate, acute pancreatitis

                Comments

                Comment on this article